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GLP-1 RAs, whose mechanisms of action involve incretin hormones, exhibit several favourable effects, including weight reduction through regulating appetite by affecting brain areas and gastric emptying time and rate, stimulating insulin secretion without hypoglycaemia and have anti-inflammatory properties that contribute to reducing atherosclerosis
Shitara Y, Sugiyama Y
Phentermine is a prescription oral appetite suppressant approved by the FDA in 1959 for short-term weight management, says Fatima Cody Stanford, MD, MPH, MPA, an obesity medicine physician scientist, educator and policy maker at Massachusetts General Brigham and Harvard Medical School
Semaglutide is part of the new generation of GLP-1 RA medications, which have greater weight loss efficacy than liraglutide ( 7 )
These results indicate that the activation of microglia and astrocytes into DAM and DAA is involved in neurodegeneration in GCLC-KO mice
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